CTGF promotes osteosarcoma angiogenesis by regulating miR-543/angiopoietin 2 signaling
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چکیده
منابع مشابه
ΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis.
The tumor suppressor gene p53 and its family members p63/p73 are critical determinants of tumorigenesis. ΔNp63 is a splice variant of p63, which lacks the N-terminal transactivation domain. It is thought to antagonize p53-, p63-, and p73-dependent translation, thus blocking their tumor suppressor activity. In our studies of the pediatric solid tumors neuroblastoma and osteosarcoma, we find over...
متن کاملCTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d
Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a secreted protein, binds to integrins, modulates invasive behavior of certain human cancer cells. Effect of CTGF in metastasis of human osteosarcoma is unknown. We found overexpression of CTGF increasing matrix metalloproteina...
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1 Research Center on Aging and Medicine, Fudan University, Shanghai Key 9 Laboratory of Bioactive Small Molecules, Department of Physiology and 10 Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China 11 2 Department of Physiology, Hainan Medical College, Haikou, Hainan 571101, China 12 3 Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 13 China...
متن کاملCCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells.
Osteosarcoma is the most frequent bone tumor, characterized by a high metastatic potential. However, the crosstalk between chemokine (C-C motif) ligand 3 (CCL3), which facilitates tumor progression and metastasis. Vascular endothelial growth factor-A (VEGF-A), an angiogenesis inducer and a highly specific mitogen for endothelial cells, has not been well explored in human osteosarcoma. Here we d...
متن کاملTumor and Stem Cell Biology DNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
The tumor suppressor gene p53 and its family members p63/p73 are critical determinants of tumorigenesis. DNp63 is a splice variant of p63, which lacks the N-terminal transactivation domain. It is thought to antagonize p53-, p63-, and p73-dependent translation, thus blocking their tumor suppressor activity. In our studies of the pediatric solid tumors neuroblastoma and osteosarcoma, we find over...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2017
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2017.01.013